Transglutaminase 1 et ichthyose lamellaire

سطح اندوتلین-1 (ET-1) در بیماران مبتلا به اسکلرودرمی با و بدون زخم نوک انگشتان

مقدمه: اسکلرودرمی یک اختلال سیستمیک با علل ناشناخته می باشد که با ضخیم شدن پوست و درگیری ارگان های داخلی مشخص می شود. اندوتلین-1 (ET-1) در فیبروزی شدن پوست بیماران مبتلا موثر می باشد. این مطالعه با هدف بررسی سطح اندوتلین-1 در بیماران مبتلا به اسکلرودرمی با زخم نوک انگشتان و مقایسه آن با بیماران مبتلا به اسکلرودرمی بدون زخم نوک انگشتان انجام شده است. روش کار: مطالعه حاضر از نوع توصیفی- تحلیلی اس...

Transglutaminase-1 Mutations in Omani Families with Lamellar Ichthyosis

OBJECTIVE To determine the molecular basis of familial ichthyosis in three Omani families. SUBJECTS AND METHODS Nine patients from three consanguineous families, A, B, and C, were born with typical features of lamellar ichthyosis subtype including collodion membrane and maintained ectropion, and epidermal scaling through their childhood. The 4 patients from family B had more severe symptoms r...

Purification et concentrations des plasmas antitoxiques. 1 - Historique, techniques industrielles et choix de la méthode adoptee en Iran

Defective stratum corneum and early neonatal death in mice lacking the gene for transglutaminase 1 (keratinocyte transglutaminase).

The stratum corneum of the skin serves as an effective barrier for maintenance of the internal milieu against the external environment. At the cell periphery of the stratum corneum is the cell envelope, a highly insoluble membranous structure composed of precursor proteins cross-linked by epsilon-(gamma-glutamyl)lysine bonds. Transglutaminase 1 (TGase 1; keratinocyte TGase), a membrane-bound is...

1. HA NGGADA et al

10 cases . The histopathology laboratory of the UMTH provides referral services for all the hospitals and private clinics in Borno State as well as other neighbouring States in the northeastern part of Nigeria. Therefore, the aim of this study was to provide baseline data on the frequency of occurrence, age and parity of patients, clinical presentation, degenerative changes, diseases associated...